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| 产地 | France |
| 品牌 | AntibodySystem |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term. |
| 货号 | RHB86903 |
| 用途 | ELISA |
| 应用范围 | 一抗,中和抗体 |
| 抗原来源 | N/A |
| CAS编号 | |
| 保质期 | 1 year |
| 抗体名 | 抗 Human EGFR/ERBB1/HER1 纳米抗体 (SAA1038) |
| 是否单克隆 | 是 |
| 克隆性 | |
| 靶点 | EGFR/ERBB1/HER1 |
| 适应物种 | Human |
| 形态 | Liquid |
| 宿主 | XtenCHO expression |
| 标记物 | Unconjugate |
| 包装规格 | 100 μg |
| 亚型 | IgG |
| 标识物 | Unconjugate |
| 浓度 | 1 mg/ml% |
| 免疫原 | N/A |
| 是否进口 | 是 |
| 产品货号 | RHB86903 |
| 产品名称 | 抗人EGFR/ERBB1/HER1纳米抗体(克隆号SAA1038) Anti-Human EGFR/ERBB1/HER1 Nanobody (Clone SAA1038) |
| 规格与价格 | 100 μg / ¥2,300 |
| 宿主来源 | 羊驼(Alpaca) |
| 反应种属 | 人(Human) |
| 产品形态 | 无菌液体(Liquid) |
| 纯度 | >95%(SDS-PAGE) |
| 保存缓冲液 | 0.01M PBS,pH 7.4 |
| 克隆属性 | 单克隆(Monoclonal) |
| 表达系统 | 哺乳动物细胞(Mammalian Cells) |
| 分子架构 | VHH-8His-Cys-tag |
| 抗体类型 | VHH纳米抗体(单域抗体) |
| 核心应用 | ELISA |
| 靶标 | EGFR(Epidermal growth factor receptor) |
| 靶标别名 | HER1、Receptor tyrosine-protein kinase erbB-1、Proto-oncogene c-ErbB-1、ERBB1、ERBB |
| 靶标数据库编号 | UniProt P00533 |
| 纯化方式 | 镍柱(Nickel column)亲和层析纯化 |
| 内毒素水平 | <1 EU/mg |
| 稳定性与储运条件 | 4°C(短期1-2周);-20°C(12个月);-80°C(长期)。避免反复冻融。 |
| 使用限制 | 仅供科研用途(For Research Use Only) |
该纳米抗体特异性靶向人EGFR(ERBB1/HER1),为表皮生长因子受体,参与细胞增殖调控,其异常活化与多种肿-瘤进展相关。纳米抗体分子量小、亲和力高,适用于肿-瘤靶向及EGFR信号通路研究。
A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells., PMID:37954614
Non-Invasive Delivery of Negatively Charged Nanobodies by Anodal Iontophoresis: When Electroosmosis Dominates Electromigration., PMID:38675200
Detection of HER2 expression using 99mTc-NM-02 nanobody in patients with breast cancer: a non-randomized, non-blinded clinical trial., PMID:38459598
Q-TWiST Analysis of Sacituzumab Govitecan vs. Chemotherapy in Previously Treated Patients with HR+/HER2- Metastatic Breast Cancer., PMID:40136373
Efficient Tumor-Targeted Photosensitizer Based on Nanobody-Coupled Pyropheophorbide-a for Precise Photodynamic Therapy of Tumors., PMID:40298399