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| 产地 | France |
| 品牌 | AntibodySystem |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term. |
| 货号 | RHB86901 |
| 用途 | ELISA,FCM |
| 应用范围 | 一抗,中和抗体 |
| 抗原来源 | N/A |
| CAS编号 | |
| 保质期 | 1 year |
| 抗体名 | 抗 Human EGFR/ERBB1/HER1 纳米抗体 (SAA0792) |
| 是否单克隆 | 是 |
| 克隆性 | |
| 靶点 | EGFR/ERBB1/HER1 |
| 适应物种 | Human |
| 形态 | Liquid |
| 宿主 | XtenCHO expression |
| 标记物 | Unconjugate |
| 包装规格 | 100 μg |
| 亚型 | IgG |
| 标识物 | Unconjugate |
| 浓度 | 1 mg/ml% |
| 免疫原 | N/A |
| 是否进口 | 是 |
| 产品货号 | RHB86901 |
| 产品名称 | Anti-Human EGFR/ERBB1/HER1 Nanobody (SAA0792) |
| 规格 | 100 μg |
| 价格 | 2300 |
| 宿主 | Alpaca |
| 亚型 | VHH-8His-Cys-tag |
| 种属反应性 | Human |
| 状态 | Liquid |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 纯度 | >95% as determined by SDS-PAGE. |
| 克隆类型 | Monoclonal |
| 应用实验 | ELISA, FCM |
| 靶点 | HER1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, EGFR, ERBB1, ERBB |
| 纯化方式 | Purified by Nickel column. |
| 内毒素水平 | Please contact with the lab for this information. |
| Accession号 | P00533 |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 克隆号 | SAA0792 |
| 备注 | For research use only. |
该纳米抗体特异性识别人EGFR(ERBB1/HER1),属于表皮生长因子受体,调控细胞增殖与迁移,异常激活和肿-瘤发生密切相关。纳米抗体尺寸小、组织穿透性优异,适用于肿-瘤靶向及信号通路机制研究。
前沿相关研究:
Antitumor Activity of a Bispecific Chimera Targeting EGFR and Met in Gefitinib-Resistant Non-Small Cell Lung Cancer., PMID:39586988
Editorial Note: Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling., PMID:39630016
Publisher Correction: Presence of EGF ligand restricts the binding ability of EgB4 nanobody to EGFR extracellular domain., PMID:40185852
Comparative Kidney Uptake of Nanobody-Based PET Tracers Labeled with Various Fluorine-18-Labeled Prosthetic Groups., PMID:39680709
The generation of a novel HER2-targeting nano PE25 immunotoxin with superior anti-tumor activity and high productivity., PMID:40086588
A HER2 Specific Nanobody-Drug Conjugate: Site-Selective Bioconjugation and In Vitro Evaluation in Breast Cancer Models., PMID:39860260
Reconstituting the immune killing functions and improving the pharmacokinetics of nanobodies by rhamnolipid conjugation., PMID:39637990
AntibodySystem于2019年创立于法国,专注于生命科学研究领域蛋白、抗体及试剂盒的研发与生产。致力于为 生命科学基础研究者提供高质量的科研试剂产品。
【核心产品线】 核心产品囊括:病毒/细菌相关抗体&蛋白、In Vivo功能性抗体、低背景流式抗体、高特异性纳米抗体、活性蛋白、PK/ADA试剂盒、特色小分子抗体、DNA/RNA抗体、传统多抗、经典内参及标签抗体。