一、中文名称：米拉组单抗，Milatuzumab (CD74) 抗体, 单克隆，Milatuzumab (CD74) Antibody, Monoclonal，Milatuzumab (CD74) 抗体, 单克隆,Milatuzumab (CD74) Antibody, Monoclonal
二、产品描述：Milatuzumab (hLL1; MEDI-115) 是一种人源化抗 CD74 单克隆抗体。CD74 是一种完整的膜蛋白，与促进 B 细胞生长和存活有关。Milatuzumab 导致自由基氧的产生和线粒体膜电位的丧失。 Milatuzumaba 还降低 CD20/CD74 聚集体和细胞粘附，从而导致细胞死亡。
三、产品详情：
货号：DHC08001
表达系统：Mammalian Cells
种属反应性：Human
宿主：Humanized
同种型：IgG1-kappa
克隆类型：Monoclonal
靶标：HLA-DR antigens-associated invariant chain, HLA class II histocompatibility antigen gamma chain, CD74, CLIP, Ia antigen-associated invariant chain, DHLAG, Ii
浓度：1.77 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession 号：P04233
克隆号：Milatuzumab
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
别名：CD74-DOX (ADC), MEDI-115, hLL1, hLL1-DOX (ADC), CAS: 899796-83-9
四、参考文献：
1. Gateways to clinical trials. PMID: 19455266
2. CD74 expression is increased in high-grade, invasive urothelial carcinoma of the bladder. PMID: 22905972
3. The anti-CD74 humanized monoclonal antibody, milatuzumab, which targets the invariant chain of MHC II complexes, alters B-cell proliferation, migration, and adhesion molecule expression. PMID: 22404985
4. CD74: a new candidate target for the immunotherapy of B-cell neoplasms. PMID: 17875789
5. Milatuzumab: a promising new agent for the treatment of lymphoid malignancies. PMID: 19053886
6. Milatuzumab-conjugated liposomes as targeted dexamethasone carriers for therapeutic delivery in CD74+ B-cell malignancies. PMID: 23209030
7. The combination of milatuzumab, a humanized anti-CD74 antibody, and veltuzumab, a humanized anti-CD20 antibody, demonstrates activity in patients with relapsed and refractory B-cell non-Hodgkin lymphoma. PMID: 25847298
8. Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma. PMID: 21228331
9. ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo. PMID: 25937048
10. Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas. PMID: 22271448
11. CD74 interferes with the expression of fas receptor on the surface of lymphoma cells. PMID: 25304249
12. Emerging antibodies for the treatment of multiple myeloma. PMID: 27195659
13. The secret second life of an innocent chaperone: the story of CD74 and B cell/chronic lymphocytic leukemia cell survival. PMID: 21417823
14. Prevention of acute graft-versus-host disease in a xenogeneic SCID mouse model by the humanized anti-CD74 antagonistic antibody milatuzumab. PMID: 23025988
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