一、中文名称：
Anti-HPV16 E7/Protein E7 Antibody (Nb4)，HPV16 E7/ E7蛋白(Nb4)多克隆抗体，精品蛋白抗体
二、产品描述
HPV16 E7蛋白是人乳头瘤病毒16型（高危型）的核心致癌蛋白，通过靶向宿主细胞关键调控因子（如视网膜母细胞瘤蛋白Rb）诱导细胞周期异常、抑制凋亡并促进细胞恶性转化。其与E6蛋白协同作用，通过泛素-蛋白酶体途径降解p53和Rb等抑癌蛋白，导致基因组不稳定及肿瘤发生，因此在HPV相关宫颈癌、头颈癌等发病机制研究中具有核心地位。
三、产品详情
Anti-HPV16 E7/Protein E7 Antibody (Nb4)，HPV16 E7/ E7蛋白(Nb4)多克隆抗体，精品蛋白抗体
货号：RVV08903
表达系统：Mammalian Cells
种属反应性：Human papillomavirus type 16
宿主：Mouse
同种型：VHH-mFC
克隆类型：Monoclonal
靶标：E7, Protein E7
浓度：3.97 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession 号：P03129
克隆号：Nb4
应用：ELISA, Neutralization, WB
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes. PMID: 18718623
Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulin. PMID: 17913829
The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb. PMID: 25451029
CD8+ T cell response to human papillomavirus 16 E7 is able to predict survival outcome in oropharyngeal cancer. PMID: 27669501
The E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle. PMID: 21697473
Human papillomavirus type 16 E6 and E7 gene variations associated with cervical cancer in a Han Chinese population. PMID: 30981880
The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. PMID: 10228159
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