一、中文名称:Research Grade Onercept (DHB94438),研究级Onercept类似物,奥那西普
二、产品描述
Onercept 是一种重组的可溶性人肿瘤坏死因子-αp55 受体,可用于克罗恩病研究。
三、产品详情
名称:Research Grade Onercept (DHB94438)
别名:Onercept (USAN/INN), r-hTBP, R-HTBP-1, R-TBP-1, rTBP-1, TBP, TBP 1, TBP I, TNF-BP1, Tumour necrosis factor binding protein 1
货号:DHB94438
表达系统:Mammalian Cells
种属反应性:Human
同种型:Glycoprotein TNF-bp (Tumor necrosis factor-binding protein, TBP1)
克隆类型:Monoclonal
靶标:TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1
浓度:1 mg/ml
内毒素水平:Please contact with the lab for this information.
纯度:>95% as determined by SDS-PAGE.
纯化方式:Protein A/G purified from cell culture supernatant.
Accession号:P01375
克隆号:Onercept
应用:Research Grade Biosimilar
状态:Liquid
保存溶液:0.01M PBS, pH 7.4.
稳定性和存储:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献:
Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease.PMID:26896086
Clinical development of onercept, a tumor necrosis factor binding protein, in psoriasis.PMID:20718590
Onercept. Serono.PMID:14758777
Onercept for moderate-to-severe Crohn's disease: a randomized, double-blind, placebo-controlled trial.PMID:16797249
Psoriatic arthritis.PMID:15379770
New biologic therapeutics for ulcerative colitis and Crohn's disease.PMID:24502344
Population pharmacokinetics of onercept in healthy subjects.PMID:16372827
Gateways to clinical trials.PMID:12743628
Treatment of active Crohn's disease with onercept (recombinant human soluble p55 tumour necrosis factor receptor): results of a randomized, open-label, pilot study.PMID:12534402
Anti-TNF therapy in Crohn's disease.PMID:15669643
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