一、中文名称：Research Grade Olamkicept (DHC15807)，研究级Olamkicept 类似物
二、产品描述
Olamkicept (FE-301) 是一种可溶性 gp130-Fc-融合蛋白，通过结合可溶性 IL-6受体/IL-6复合物选择性地抑制白细胞介素6 (IL-6)反式信号。
三、产品详情
名称：Research Grade Olamkicept (DHC15807)
别名：FE 999301,FE-301,FE-999301,gp130-Fc, CAS: 1702282-14-1
货号：DHC15807
表达系统：Mammalian Cells
种属反应性：Human
宿主：Human
同种型：Fusion - [IL6ST (interleukin 6 signal transducer, "interleukin 6 signal transducer (gp130, oncostatin M receptor)", CD130, GP130, "gp130, oncostatin M receptor", "Interleukin-6 receptor subunit beta") 23-617]2 - IGHG1 Fc (Fragment constant)
靶标：Hybridoma growth factor, BSF-2, IFN-beta-2, CDF, IL6, Interleukin-6, IL-6, B-cell stimulatory factor 2, Interferon beta-2, IFNB2, CTL differentiation factor, sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P05231 & P08887
克隆号：Olamkicept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Effect of Induction Therapy With Olamkicept vs Placebo on Clinical Response in Patients With Active Ulcerative Colitis: A Randomized Clinical Trial.PMID:36881032
Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease.PMID:33667488
Targeting IL-6 trans-signalling: past, present and future prospects.PMID:37069261
Olamkicept(sgp130Fc): The missing trial in Neuromyelitis Optica Spectrum Disorder.PMID:35798242
Interleukin-6: obstacles to targeting a complex cytokine in critical illness.PMID:33872590
Satralizumab might not be enough. Olamkicept (sgp130Fc) in Neuromyelitis Optica Spectrum Disorder.PMID:35835028
Corrigendum to "Olamkicept(sgp130Fc): The missing trial in Neuromyelitis Optica Spectrum Disorder" [Clinical Immunology 241 (2022) 109072].PMID:36150949
A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling.PMID:34765926
Safety, tolerability, and pharmacokinetics of single- and multiple-ascending doses of olamkicept: Results from randomized, placebo-controlled, first-in-human phase I trials.PMID:38769747
Case Report: Arterial Wall Inflammation in Atherosclerotic Cardiovascular Disease is Reduced by Olamkicept (sgp130Fc).PMID:35754497
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