一、中文名称：Anti-Human FOXP3 Monoclonal Antibody (1A209)(MHJ52502)，FOXP3抗体
二、产品描述
nti FOXP3 Antibody，FOXP3 Protein，FOXP3抗体，FOXP3是转录调节因子叉头/翼螺旋家族的成员。FOX转录因子家族是一大类蛋白质，它们共享一个共同的DNA结合域，称为翼螺旋或叉头结构域。FOXP3作为转录抑制因子并调节T细胞活化，其在CD4 T细胞中的过度表达导致活化诱导的细胞因子产生和增殖的减弱。在调节性T（Treg）细胞中，FOXP3对Treg抑制功能至关重要，其表达导致IL-17表达的抑制。FOXP3基因突变导致IPEX，这是一种致命的X连锁遗传性疾病，以免疫失调为特征。FOXP3蛋白对正常的免疫稳态至关重要。具体而言，FOXP3通过DNA结合叉头结构域抑制转录，从而调节T细胞活化。抗FOXP3抗体对于对转录因子活性、多内分泌疾病、免疫调节和DNA结合研究感兴趣的研究人员非常有用。
三、产品详情
名称：Anti-Human FOXP3 Monoclonal Antibody (1A209) (MHJ52502)
别名：Forkhead box protein P3, Scurfin, Forkhead box protein P3, C-terminally processed, Forkhead box protein P3 41 kDa form, FOXP3, IPEX, JM2，FOXP3抗体
货号：MHJ52502
种属反应性：Human
宿主：Mouse
同种型：IgG1
克隆类型：Monoclonal
免疫原：Recombinant Human FOXP3 protein.
靶标：Forkhead box protein P3, Scurfin, Forkhead box protein P3, C-terminally processed, Forkhead box protein P3 41 kDa form, FOXP3, IPEX, JM2
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：Q9BZS1
克隆号：1A209
应用：ELISA, FCM, WB
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
FOXP3 and its role in the immune system. PMID: 20429413
Control of regulatory T-cell differentiation and function by T-cell receptor signalling and Foxp3 transcription factor complexes. PMID: 32022254
Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers. PMID: 27111280
FOXP3 regulatory T cells on prognosis of breast cancer. PMID: 37458005
FOXP3 (in)stability and cancer immunotherapy. PMID: 38547750
Foxp3(+) Regulatory T Cells in Bone and Hematopoietic Homeostasis. PMID: 31551927
FOXP3: A Player of Immunogenetic Architecture in Lung Cancer. PMID: 38674427
FoxP3 Expression in Macrophages, Cancer, and B Cells-Is It Real? PMID: 27339600
Alternative Splicing of FOXP3-Virtue and Vice. PMID: 29593749
The Role of FOXP3 on Tumor Metastasis and Its Interaction with Traditional Chinese Medicine. PMID: 36235242
IL-17A-Producing Foxp3(+) Regulatory T Cells and Human Diseases. PMID: 29093649
FOXP3: genetic and epigenetic implications for autoimmunity. PMID: 23313429
Human FOXP3 and cancer. PMID: 20498631
FOXP3 expression in tumor cells and implications for cancer progression. PMID: 22674548
Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application. PMID: 37224732
FOXP3 Predicts Response to Treatment in Mycosis Fungoides. PMID: 34477071
FoxP3 recognizes microsatellites and bridges DNA through multimerization. PMID: Update in:
The prognostic values of FOXP3(+) tumor-infiltrating T cells in breast cancer: a systematic review and meta-analysis. PMID: 36692642
Co-expression of Foxp3 and Helios facilitates the identification of human T regulatory cells in health and disease. PMID: 37350974
FOXP3-specific immunity. PMID: 24498544
Searching for the Achilles Heel of FOXP3. PMID: 24350059
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