一、中文名称：Anti-Human TRBC1 Antibody (Jovi-1) (FHK13810)，人T细胞受体β-1链C区抗体
二、产品描述
跨膜蛋白TCR由两个二硫化物连接的多肽链组成：α和β链，γ和δ链。每条多肽链由一个可变区和一个恒定区组成。TRBC1是t细胞受体(TCR) β链的恒定区。TRBC1呈递于T细胞表面，并通过抗原呈递细胞（APC）显示识别的肽主组织相容性（MH）（pMH）。TRBC1参与适应性免疫反应，在T细胞治疗中得到了很好的研究。
三、产品详情
名称：Anti-Human TRBC1 Antibody (Jovi-1) (FHK13810)
别名：T cell receptor beta constant 1,TRBC1
货号：FHK13810
种属反应性：Human
宿主：Mouse
同种型：IgG2a, kappa
克隆类型：Monoclonal
偶联物：Unconjugated
靶标：TRBC1, T cell receptor beta constant 1
浓度：3.76 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P01850
克隆号：Jovi-1
应用：ELISA, FCM, IF
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. (FHK13810)
四、参考文献：
Emerging Role of T-cell Receptor Constant beta Chain-1 (TRBC1) Expression in the Flow Cytometric Diagnosis of T-cell Malignancies. PMID: 33673033
Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms. PMID: 32333725
Cytoplasmic TRBC1 Expression in T-ALL and AITL. PMID: 36197794
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies. PMID: 29131157
High-Sensitive TRBC1-Based Flow Cytometric Assessment of T-Cell Clonality in Talphabeta-Large Granular Lymphocytic Leukemia. PMID: 35053571
Anti-TRBC1 Antibody-Based Flow Cytometric Detection of T-Cell Clonality: Standardization of Sample Preparation and Diagnostic Implementation. PMID: 34503189
Flow Cytometric Evaluation of Cytoplasmic TRBC1 Expression. PMID: 35136905
TRBC1 expression assessed by flow cytometry as a novel marker of clonality in cutaneous alphabeta T-cell lymphomas with peripheral blood involvement. PMID: 35606929
Analysis of the Expression of the TRBC1 in T lymphocyte tumors. PMID: 33867734
TRBC1 enables identification of an otherwise immunophenotypically silent case of angioimmunoblastic T-cell lymphoma. PMID: 38175375
Restricted TRBC1 expression: A clonality marker for circulating Sezary cells. PMID: 34342917
Correction to: Cytoplasmic TRBC1 Expression in T-ALL and AITL. PMID: 36762619
The expressional characteristics and diagnostic values of TRBC1 in mature T-cell lymphoma. PMID: 36709135
Utility of TRBC1 Expression in the Diagnosis of Peripheral Blood Involvement by Cutaneous T-Cell Lymphoma. PMID: 33049270
Pre-depletion of TRBC1+ T cells promotes the therapeutic efficacy of anti-TRBC1 CAR-T for T-cell malignancies. PMID: 33218364
PD-1 combined with TRBC1 and pan-T cell antibodies for robustly monitoring angioimmunoblastic T-cell lymphoma. PMID: 36160159
Computational discovery of binding mode of anti-TRBC1 antibody and predicted key amino acids of TRBC1. PMID: 35110642
TRBC1 immunohistochemistry distinguishes cutaneous T-cell lymphoma from inflammatory dermatitis: A retrospective analysis of 39 cases. PMID: 38061444
Flow Cytometric Evaluation of Surface and Cytoplasmic TRBC1 Expression in the Differential Diagnosis of Immature T-Cell Proliferations. PMID: 34302330
Rapid evaluation of T cell clonality in the diagnostic work-up of mature T cell neoplasms: TRBC1-based flow cytometric assay experience. PMID: 36183675
Reliable Detection of T-Cell Clonality by Flow Cytometry in Mature T-Cell Neoplasms Using TRBC1: Implementation as a Reflex Test and Comparison with PCR-Based Clonality Testing. PMID: 35285909
TRBC1-targeting antibody-drug conjugates for the treatment of T cell cancers. PMID: 38538786
Diagnostic utility of the lymphoid screening tube supplemented with TRBC1 for the assessment of T-cell clonality. PMID: 36856131
Evaluation of Molecular Simulations and Deep Learning Prediction of Antibodies' Recognition of TRBC1 and TRBC2. PMID: 37753972
Broadening the horizon: potential applications of CAR-T cells beyond current indications. PMID: 38090582
Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies. PMID: 38383515
Evaluation of T-cell clonality by anti-TRBC1 antibody-based flow cytometry and correlation with T-cell receptor sequencing. PMID: 38098188
Dimorphism in the T-cell receptor constant region affects T-cell function, phenotype and HIV outcome. PMID: 30932962
Corrigendum to < Rapid evaluation of T cell clonality in the diagnostic work-up of mature T cell neoplasms: TRBC1-based flow cytometric assay experience>. PMID: 36801075
Single Antibody Detection of T-Cell Receptor αβ Clonality by Flow Cytometry Rapidly Identifies Mature T-Cell Neoplasms and Monotypic Small CD8-Positive Subsets of Uncertain Significance. PMID: 30972977
Integration of T-cell clonality screening using TRBC-1 in lymphoma suspect samples by flow cytometry. PMID: 38010106
sTRBC1 and cyTRBC1 Expression Distinguishes Indolent T-Lymphoblastic Proliferations From T-Lymphoblastic Leukemia/Lymphoma. PMID: 37515427
Single-Antibody Evaluation of T-Cell Receptor β Constant Chain Monotypia by Flow Cytometry Facilitates the Diagnosis of T-Cell Large Granular Lymphocytic Leukemia. PMID: 33438036
Utility of a Simple and Robust Flow Cytometry Assay for Rapid Clonality Testing in Mature Peripheral T-Cell Lymphomas. PMID: 30715093
Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry. PMID: 38424120
Constructing a 10-core genes panel for diagnosis of pediatric sepsis. PMID: 33274532
T-cell clones of uncertain significance are highly prevalent and show close resemblance to T-cell large granular lymphocytic leukemia. Implications for laboratory diagnostics. PMID: 32404954
Influence of Genetic Polymorphisms on Clinical Outcomes of Glatiramer Acetate in Multiple Sclerosis Patients. PMID: 34683173
Differential diagnosis and identification of prognostic markers for peripheral T-cell lymphoma subtypes based on flow cytometry immunophenotype profiles. PMID: 36466894
Inflammatory Gene Expression in Whole Peripheral Blood at Early Stages of Sporadic Amyotrophic Lateral Sclerosis. PMID: 29081763
MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer. PMID: 28409241
A Decentralized Kidney Transplant Biopsy Classifier for Transplant Rejection Developed Using Genes of the Banff-Human Organ Transplant Panel. PMID: 35619722
Computational discovery of binding mode of anti-TRBC1 antibody and predicted key amino acids of TRBC1. PMID: 35110642
Anti-TRBC1 Antibody-Based Flow Cytometric Detection of T-Cell Clonality: Standardization of Sample Preparation and Diagnostic Implementation. PMID: 34503189
Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies. PMID: 38383515
Generation of monoclonal antibodies against a human T cell receptor beta chain expressed in transgenic mice. PMID: 1284120
High-Sensitive TRBC1-Based Flow Cytometric Assessment of T-Cell Clonality in Tαβ-Large Granular Lymphocytic Leukemia. PMID: 35053571
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