一、中文名称：磷酸钠协同转运蛋白SLC34A2多克隆抗体

二、产品描述

2b型钠依赖性磷酸盐转运体（NaPi-IIb）是一种多通道的膜蛋白，由690个氨基酸组成，是溶质载体SLC34家族的成员，该家族由NaPi-IIa（SLC34A1）、NaPi-IIb（SLC34A2）和NaPi-IIc（SLC34A3）构成。其中NaPi-IIb蛋白通过钠离子共转运介导无机磷酸盐进入上皮细胞，负责维持全身的磷酸盐平衡。NaPi-IIb包含两个保守序列的倒置重复单元，由一个大的细胞外环连接，两个末端都位于细胞膜内。NaPi-IIb是由基因SLC34A2编码而来，SLC34A2的cDNA于1999年首次从人类小肠和肺部cDNA文库中分离并克隆出来，虽然SLC34A2在人类的各种组织中都有表达，但在肺、小肠和肾脏中的表达量最高。最近的研究发现SLC34A2的表达在NSCLC的手术样本和正常组织之间有明显的差异，并且SLC34A2在肺腺癌细胞系A549中下调，上调SLC34A2的表达可以明显抑制A549的细胞活力和体外侵袭。这些结果表明，SLC34A2可能在NSCLC的发展中发挥重要作用。除肺癌外，SLC34A2主要影响的另一疾病就是卵巢癌，其在大部分上皮性卵巢癌中过表达。此外，SLC34A2的异常表达还与肺泡微石症（PAM）、低磷血症、不孕症、睾丸微石症（TM）和其他恶性肿瘤（包括甲状腺癌、乳腺癌等）有关。

三、相关产品

Anti-SLC34A2/NaPi2b Polyclonal Antibody (PHB65401)

Anti-SLC34A2/ NaPi2b Polyclonal Antibody (PHB65402)

四、产品详情

名称：Anti-SLC34A2/NaPi2b Polyclonal Antibody (PHB65401)

别名：Sodium/phosphate cotransporter 2B, Na(+)-dependent phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, Sodium-dependent phosphate transport protein 2B, NaPi3b, NaPi-2b,NaPi2b,SLC34A2, Solute carrier family 34 member 2, Sodium-phosphate transport protein 2B

货号：PHB65401

种属反应性：Human, Rat

宿主：Rabbit

同种型：IgG

克隆类型：Polyclonal

免疫原：E. coli - derived recombinant Human SLC34A2/NaPi2b (Ser251-Asp361).

经测试应用：ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

靶标：Sodium/phosphate cotransporter 2B, Na(+)-dependent phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, Sodium-dependent phosphate transport protein 2B, NaPi3b, NaPi-2b, SLC34A2, Solute carrier family 34 member 2, Sodium-phosphate transport protein 2B

纯化方式：Purified by antigen affinity column.

Accession号：O95436

应用：ELISA, IHC, WB

状态：Liquid

保存溶液：0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

稳定性和存储：Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. (PHB65401)

五、参考文献：

SLC34A2 promotes cancer proliferation and cell cycle progression by targeting TMPRSS3 in colorectal cancer. PMID: 34929599

The role of SLC34A2 in intestinal phosphate absorption and phosphate homeostasis. PMID: 30343332

Knockdown of SLC34A2 inhibits cell proliferation, metastasis, and elevates chemosensitivity in glioma. PMID: 30592329

Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases. PMID: 34944522

SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms. PMID: 32005974

The SLC34A2-ROS-HIF-1-induced up-regulation of EZH2 expression promotes proliferation and chemo-resistance to apoptosis in colorectal cancer. PMID: 30038060

New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review. PMID: 37259144

SLC34A2 Gene mutation of pulmonary alveolar microlithiasis: report of four cases and review of literatures. PMID: 23164546

Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis. PMID: 35443721

SLC34A2 promotes neuroblastoma cell stemness via enhancement of miR-25/Gsk3beta-mediated activation of Wnt/beta-catenin signaling. PMID: 30868061

SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma. PMID: 38720472

SLC34A2 Targets in Calcium/Phosphorus Homeostasis of Mammary Gland and Involvement in Development of Clinical Mastitis in Dairy Cows. PMID: 38731279

Knockdown of SLC34A2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Invasion. PMID: 28281971

Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality. PMID: 33846411

SLC34A2 regulates miR-25-Gsk3beta signaling pathway to affect tumor progression in gastric cancer stem cell-like cells. PMID: 29178392

Is SLC34A2 Associated With Concomitant Calcium Metabolism Disorder in Pulmonary Alveolar Microlithiasis (PAM)? PMID: 37217383

NaPi2b expression in a large surgical Non-Small Cell Lung Cancer (NSCLC) cohort. PMID: 34953676

Antibody-Drug Conjugates in Gynecologic Cancer. PMID: 37229642

(213)Bi/(211)At-Labeled MX35, an anti-sodium-dependent phosphate transport protein 2b (NaPi2b) murine monoclonal antibody. PMID: 22675742

Toward a Topology-Based Therapeutic Design of Membrane Proteins: Validation of NaPi2b Topology in Live Ovarian Cancer Cells. PMID: 35911971

Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer. PMID: 34504954

Development of potent non-acylhydrazone inhibitors of intestinal sodium-dependent phosphate transport protein 2b (NaPi2b). PMID: 35917765

Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors. PMID: 35346844

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. PMID: 30158152

Discovery of Gut-Restricted Small-Molecule Inhibitors of Intestinal Sodium-Dependent Phosphate Transport Protein 2b (NaPi2b) for the Treatment of Hyperphosphatemia. PMID: 35034442

Development of monoclonal antibodies specific for the human sodium-dependent phosphate co-transporter NaPi2b. PMID: 18724815

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