一、中文名称：InVivoMAb Anti-Mouse CD279/PDCD1/PD1 Antibody (RMP1-14)(VMH02202)，抗小鼠PD1抗体/体内中和抗体/活性抗体
二、产品描述
PD-1（程序性死亡受体1，Programmed Death 1），是一种在活化的T细胞、B细胞和巨噬细胞表面表达的免疫检查点蛋白，主要通过与其配体PD-L1（程序性死亡配体1）和PD-L2结合，调节免疫反应并防止过度的免疫应答。PD-1及其配体的相互作用在维持外周耐受性和预防自身免疫性疾病方面起着关键作用。然而，在肿瘤微环境中，癌细胞常常高表达PD-L1，从而抑制T细胞活性，帮助逃避免疫系统的攻击。近年来，针对PD-1/PD-L1通路的免疫检查点抑制剂（如纳武利尤单抗和帕博利珠单抗）已被广泛应用于多种癌症治疗，显著提高了患者的生存率和生活质量。这些药物通过阻断PD-1与PD-L1的结合，恢复T细胞对肿瘤细胞的杀伤能力。
三、产品详情
名称：InVivoMAb Anti-Mouse CD279/PDCD1/PD1 Antibody (RMP1-14) (VMH02202)
别名： Programmed cell death protein 1，CD279，hPD-1，PDCD1，Programmed Cell Death 1，Systemic Lupus Erythematosus Susceptibility 2，Protein PD-1，PD1，Programmed Cell Death 1 Protein，CD279 Antigen，HPD-L，HSLE1，SLEB2，PD-1，Programmed Cell Death 1 Receptor
货号：VMH02202
种属反应性：Mouse
宿主：Mouse
同种型：IgG2a, kappa
克隆类型：Monoclonal
靶标：Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：Q02242
克隆号：RMP1-14
应用：Neutralization
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions. PMID: 32324337
Utility of CD279/PD-1 immunohistochemistry in the evaluation of benign and neoplastic T-cell-rich bone marrow infiltrates. PMID: 24926091
PD-1 Blockers. PMID: 26317459
Editorial: Immune Checkpoint Molecules and Cancer Immunotherapy. PMID: 30568661
Expression of PD-1 (CD279) and FoxP3 in diffuse large B-cell lymphoma. PMID: 25011996
Artesunate upregulates the expression of CD39, CD279 and granzyme B in CD4(+) and CD8(+) T lymphocytes of patients with lung cancer. PMID: 35583064
PD1 (CD279) and PD-L1 (CD274, B7H1) expression in primary central nervous system lymphomas (PCNSL). PMID: 24359606
Different Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages. PMID: 34675601
Effects of Tussilago farfara L. Polysaccharides on the Expression of PD-1 (CD279) and PD-L1 (CD274) in Peripheral Blood and Tumor Tissue Lymphocytes in Mice with Lewis Lung Carcinoma. PMID: 32749562
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy. PMID: 37716115
Next generation of anti-immune checkpoints antibodies. PMID: 31903901
The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow. PMID: 29304116
CoViD-19 Immunopathology and Immunotherapy. PMID: 32308263
Expression patterns of the immunosuppressive proteins PD-1/CD279 and PD-L1/CD274 at different stages of cutaneous T-cell lymphoma/mycosis fungoides. PMID: 22094231
Peptide Blocking CTLA-4 and B7-1 Interaction. PMID: 33419027
PDCD1 and PDCD1LG1 polymorphisms affect the susceptibility to multiple myeloma. PMID: 31620907
The association between polymorphisms in the PDCD1 gene and the risk of cancer: A PRISMA-compliant meta-analysis. PMID: 27749524
A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC? PMID: 33808740
PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases. PMID: 32937024
Epigenetic and Genetic Regulation of PDCD1 Gene in Cancer Immunology. PMID: 30178256
Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis. PMID: 35762356
Tumor Mutational Burden and Response Rate to PD-1 Inhibition. PMID: 29262275
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. PMID: 1396582
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior. PMID: 37348508
Identification of PDCD1 as a potential biomarker in acute rejection after kidney transplantation via comprehensive bioinformatic analysis. PMID: 36776400
CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells. PMID: 37691307
PD1 signal transduction pathways in T cells. PMID: 28881701
Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma. PMID: 35042524
Biomarkers for Predicting Efficacies of Anti-PD1 Antibodies. PMID: 31417907
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy. PMID: 34539412
Revisiting the PD-1 pathway. PMID: 32948597
PD1 Blockade in Cancer: Impact on Myeloid Cells. PMID: 32459997
Gut Microbiota: A Promising Milestone in Enhancing the Efficacy of PD1/PD-L1 Blockade Therapy. PMID: 35252014
Understanding the role of PD-L1/PD1 pathway blockade and autophagy in cancer therapy. PMID: 28367063
PD1 is transcriptionally regulated by LEF1 in mature T cells. PMID: 37523793
Emerging concepts in PD-1 checkpoint biology. PMID: 34006473
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior. PMID: 37348508
Quantification of the anti-murine PD-1 monoclonal antibody RMP1-14 in BALB/c mouse plasma by liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study. PMID: 31832706
Antibody-mediated depletion of programmed death 1-positive (PD-1+) cells. PMID: 35820540
The Programmed Cell Death Ligand-1/Programmed Cell Death-1 Pathway Mediates Pregnancy-Induced Analgesia via Regulating Spinal Inflammatory Cytokines. PMID: 34524124
Combination of PD-1 Checkpoint Blockade and Botulinum Toxin Type A1 Improves Antitumor Responses in Mouse Tumor Models of Melanoma and Colon Carcinoma. PMID: 37403798
An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. PMID: 33447829
A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis. PMID: 28288993
Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1. PMID: 31661001
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