一、中文名称：
Anti-Mouse CD25/IL2RA Antibody (PC61/PC61.5.3) (FMB95810)，抗小鼠 CD25 / 白细胞介素 2 受体 α 链抗体（PC61/PC61.5.3）（FMB95810），精品蛋白抗体试剂盒
二、产品描述
Anti-Mouse CD25/IL2RA Antibody (PC61/PC61.5.3) 是一种特异性单克隆抗体，靶向小鼠体内的 CD25，即白细胞介素 2 受体 α 链（IL2RA）。该抗体主要在活化的 T 淋巴细胞、调节性 T 细胞（Treg）表面表达，且在这些细胞处于活跃状态时表达量显著上升。当机体免疫系统被激活，该抗体能够快速且特异性地与 CD25 紧密结合，阻断白细胞介素 2（IL-2）与 IL2RA 的相互作用，从而干扰 T 淋巴细胞和 Treg 细胞的活化与增殖信号传导。临床前研究和小鼠免疫相关疾病模型实验表明，使用此抗体可有效调节免疫反应，在小鼠自身免疫性疾病模型中，它抑制了过度活化的免疫细胞，缓解了炎症反应，对自身免疫性疾病的发病机制研究以及新型免疫调节药物研发具有重要价值。
三、产品详情
名称：Anti-Mouse CD357/TNFRSF18/GITR Antibody (DTA-1) (FMJ89810)体内中和抗体，活性抗体
货号：FMB95810
种属反应性：Mouse
宿主：Rat
同种型：IgG1, lambda
克隆类型：Monoclonal
偶联物：Unconjugated
靶标：Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, p55, CD25, Il2ra, Il2r
浓度：2.01 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P01590
克隆号：PC61/PC61.5.3
应用：FCM, FuncS
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1 - 2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage.PMID:30586752
Prostate Cancer Incidence is Correlated to Total Meat Intake– a Cross-National Ecologic Analysis of 172 Countries.PMID:30139230
In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytes.PMID:20039297
Green-solvent-processed molecular solar cells.PMID:25389005
Impact of Regulatory T Cells on Innate Immune Cells in a Pre-Sensitized Heart Transplant Model.PMID:29650945
[Mechanism of regulatory T cells in heat stroke-induced acute kidney injury].PMID:37308234
High and low affinity IL 2 receptors: analysis by IL 2 dissociation rate and reactivity with monoclonal anti-receptor antibody PC61.PMID:3934270
Calcitriol restrains microglial M1 polarization and alleviates dopaminergic degeneration in hemiparkinsonian mice by boosting regulatory T-cell expansion.PMID:38346718
Suppression of tumour metastasis in a murine osteosarcoma model with anti-CD25 monoclonal antibody treatment.PMID:21187484
Partial depletion of CD69low-expressing natural regulatory T cells with the anti-CD25 monoclonal antibody PC61.PMID:17212768
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