一、中文名称:
Anti-Human TSHR/LGR3 Antibody (K1-70) (FHD18120),促甲状腺素受体TSHR/LGR3 Antibody (K1-70),精品蛋白抗体试剂盒
二、产品描述
促甲状腺素受体(Thyrotropin receptor, TSHR)是一种细胞表面糖蛋白受体,属于A类G蛋白偶联受体(GPCRs)超家族的LGR亚家族,并与Gs蛋白相连接。TSHR主要在甲状腺组织中表达,但其mRNA和蛋白也存在于神经组织、免疫细胞、眼肌、骨骼、脂肪细胞、红细胞、卵巢和肝脏等部位。TSHR接受促甲状腺激素(Thyrotropin, TSH)信号刺激后,启动偶联信号通路,促进下游效应基因的表达,刺激细胞生成甲状腺激素(T4)和三碘甲状腺激素(T3),对甲状腺的生长和功能至关重要。
三、产品详情
名称:Anti-Human TSHR/LGR3 Antibody (K1-70) (FHD18120),促甲状腺素受体TSHR/LGR3 Antibody (K1-70),体内中和抗体,活性抗体
货号:FHD18120
种属反应性:Human
宿主:Mouse
同种型:IgG2a, lambda
克隆类型:Monoclonal
偶联物:Unconjugated
靶标:Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3, RHD18102
浓度:0.56 mg/ml
内毒素水平:Please contact with the lab for this information.
纯度:>95% as determined by SDS - PAGE.
纯化方式:Protein A/G purified from cell culture supernatant.
Accession号:P16473
克隆号:K1 - 70
应用:Blocking, ELISA, FCM
状态:Liquid
保存溶液:0.01M PBS, pH 7.4.
稳定性和存储:Use a manual defrost freezer and avoid repeated freeze - thaw cycles. Store at 4°C short term (1 - 2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献:
Modulation of TSHR signaling by posttranslational modifications. PMID: 17524661
TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease. PMID: 37690235
Variant of TSHR is Not a Frequent Cause of Congenital Hypothyroidism in Chinese Han Patients. PMID: 34377013
The biology and evolution of the Dilp8-Lgr3 pathway: A relaxin-like pathway coupling tissue growth and developmental timing control. PMID: 29715504
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
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