Latikafusp抗体|Latikafusp(AMG 256)|PD-1抗体IL-21突变蛋白|佰乐博生物代理AntibodySystem
Latikafusp (AMG 256)是一种双功能融合蛋白，包含靶向PD-1的抗体和IL-21突变蛋白，旨在向PD-1+细胞提供IL-21通路刺激。Latikafusp可以启动和延长细胞毒性和记忆T细胞的活性，并诱导抗肿瘤免疫。Latikafusp具有用于实体瘤研究的潜力。Latikafusp可导致免疫原性介导的反应的产生。
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名称：Research Grade Latikafusp (AMG 256)抗体
别名：Bispecific antibody, AMG 256, AMG-256, AMG256
CAS: 2552814-07-8
货号：DHJ59501
宿主：Homo sapiens
适用物种：Human
存储缓冲区：0.01M PBS, pH 7.4.
形式：Liquid
纯度：>95%
克隆：Monoclonal
同型：IgG1-lambda2
应用：Research Grade Biosimilar
靶点：IL21R, NILR, Interleukin-21 receptor, IL-21R, IL-21 receptor, CD360, Novel interleukin receptor, Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
生物活性：Latikafusp (AMG 256) is a bifunctional fusion protein comprising a PD-1-targeting antibody and IL-21 mutein designed to deliver IL-21 pathway stimulation to PD-1+ cells. Latikafusp is designed to prime and extend the activity of cytotoxic and memory T cells and induce anti-tumor immunity. Latikafusp has the potential for solid tumors research.
内毒素水平：Please contact with the lab for this information.
UniProt：Q9HBE5 & Q15116
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
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参考文献：
[1]. Greg Durm, et al. Abstract CT205: Design and rationale of a phase 1 study evaluating AMG 256, a novel, targeted, PD-1 antibody x IL-21 mutein bifunctional fusion protein, in patients with advanced solid tumors. Clin Cancer Res. 2022 Apr 1;28(7):1294-1301. [Content Brief]
[2]. Gregory Durm, et al. 417 Design and rationale of a phase 1 study evaluating AMG 256, a novel, targeted, IL-21 receptor agonist and anti-PD-1 antibody, in patients with advanced solid tumors. Journal for ImmunoTherapy of Cancer, 2020, 8(Suppl 3).
[3]. Kroenke Met al. Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein. Front Immunol. 2024 Jan 26;15:1345473. [Content Brief]
