武汉佰乐博代理：Recombinant Mouse 2B4/SLAMF4/CD244 protein ,C- His Tag
产品链接：http://www.atagenix.com/product_detail-4880.html
纯度：>90% as determined by SDS-PAGE
内毒素：Please contact with the lab for this information.
蛋白构建：A DNA sequence encoding the mouse CD244(Gln20-Asn221) was fused with the C-terminal His Tag
表达宿主：Mammalian cells
种属：Mus musculus (Mouse)
预测分子量：22.33kDa
制剂：Supplied as solution form in PBS or lyophilized from PBS .
运输方式：In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性&储存：Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
复溶：Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
分子别名：2b4, Nmrk
Note：For research use only .
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咨询邮箱：products@biolabreagent.com
选购商城：https://www.antibodysystem.com
微信公众平台：佰乐博生物Biolab Reagents
参考文献：
2B4 co-stimulation: NK cells and their control of adaptive immune responses. PMID: 15607793
Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities. PMID: 34896980
microRNA dysregulation in neurodegenerative diseases: A systematic review. PMID: 31356849
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. PMID: 1396582
A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-α and IFN-γ production in dNK cells during Toxoplasma gondii infection. PMID: 36153598
2B4 inhibits NK-cell fratricide. PMID: 17537992
The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5). PMID: 21055385
Regulation of NK cell activity by 2B4, NTB-A and CRACC. PMID: 17981603
Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells. PMID: 16621032
Complex 2B4 regulation of mast cells and eosinophils in murine allergic inflammation. PMID: 24999594
Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry. PMID: 17786637
Role of cytochrome b5 in catalysis by cytochrome P450 2B4. PMID: 16182240
WhatSAP - 2B4 sends mixed messages in the absence of SAP. PMID: 24659462
2B4 Mediates Inhibition of CD8+ T Cell Responses via Attenuation of Glycolysis and Cell Division. PMID: 30012849
2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. PMID: 21439641
2B4+ CD8+ T cells play an inhibitory role against constrained HIV epitopes. PMID: 21256826
2B4/CD48-mediated regulation of lymphocyte activation and function. PMID: 16081768
2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses. PMID: 24493803
2B4 (CD244) is involved in eosinophil adhesion and chemotaxis, and its surface expression is increased in allergic rhinitis after challenge. PMID: 22230401
2B4-mediated activation of human natural killer cells. PMID: 11163399
Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients. PMID: 28386908
2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy. PMID: 31723059
Expression and Clinical Significance of KLRG1 and 2B4 on T Cells in the Peripheral Blood and Tumour of Patients with Cervical Cancer. PMID: 33401997
Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis. PMID: 28768726
2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. PMID: 15123744
2B4 functions as a co-receptor in human NK cell activation. PMID: 10741393
Increased attrition of memory T cells during sepsis requires 2B4. PMID: 31045575
DNAM1 and 2B4 Costimulatory Domains Enhance the Cytotoxicity of Anti-GPC3 Chimeric Antigen Receptor-Modified Natural Killer Cells Against Hepatocellular Cancer Cells in vitro. PMID: 32440221
2B4(CD244)-mediated activation of NK cells reduces metastases of B16F10 melanoma in mice. PMID: 14666660
NKG2D ligation relieves 2B4-mediated NK-cell self-tolerance in mice. PMID: 24610736
2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. PMID: 11714782
SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors. PMID: 35061505
Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases. PMID: 33841431
2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer. PMID: 30347240
SLAMF4 Is a Negative Regulator of Expansion of Cytotoxic Intraepithelial CD8+ T Cells That Maintains Homeostasis in the Small Intestine. PMID: 25678452
Chicken SLAMF4 (CD244, 2B4), a receptor expressed on thrombocytes, monocytes, NK cells, and subsets of αβ-, γδ- T cells and B cells binds to SLAMF2. PMID: 24055739
Roles of NK Cell Receptors 2B4 (CD244), CS1 (CD319), and LLT1 (CLEC2D) in Cancer. PMID: 32630303
NK Cells Equipped With a Chimeric Antigen Receptor That Overcomes Inhibition by HLA Class I for Adoptive Transfer of CAR-NK Cells. PMID: 35585985
Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity. PMID: 21622868
Gut symbiotic microbes imprint intestinal immune cells with the innate receptor SLAMF4 which contributes to gut immune protection against enteric pathogens. PMID: 28341747
2B4 and CD48: A powerful couple of the immune system. PMID: 30366105
Responses to Microbial Challenges by SLAMF Receptors. PMID: 26834746
Brief report: Decreased expression of CD244 (SLAMF4) on monocytes and platelets in patients with systemic lupus erythematosus. PMID: 28593610
The chicken SLAM family. PMID: 23064403
Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus. PMID: 26314831
The SLAM family receptors: Potential therapeutic targets for inflammatory and autoimmune diseases. PMID: 29729453
Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival. PMID: 24670806
Fine specificity and molecular competition in SLAM family receptor signalling. PMID: 24642916
SLAMF Receptor Expression Identifies an Immune Signature That Characterizes Systemic Lupus Erythematosus. PMID: 35603218
SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions. PMID: 20146065
CD244 is expressed on dendritic cells and regulates their functions. PMID: 25643613
Human Diversity in a Cell Surface Receptor that Inhibits Autophagy. PMID: 27345162
