标题：赛必妥单抗，Cibisatamab，CAS:2101242-53-7，AntibodySystem Laboratories
货号：DHC21003
产品链接：http://www.atagenix.com/product_detail-75488.html
别名：Bispecific, CEA TCB, RG-7802, RO-6958688, CAS: 2101242-53-7
简介：Cibisatamab (CEA-TCB) 是一种 T 细胞双特异性抗体，与癌细胞上的癌胚抗原 (CEA) 和 T 细胞上的 CD3 结合。Cibisatamab (CEA-TCB) 对细胞表面表达中到高水平 CEA 的癌细胞系触发 T 细胞杀伤。Cibisatamab (CEA-TCB) 可用于结直肠癌研究。
产品品牌：Antibodysystem
通用名：Cibisatamab
纯度：>95% by SDS-PAGE.
浓度：1mg/ml
Formulationicon：0.01M PBS, pH 7.4.
内毒素：Please contact with the lab for this information.
别名：Bispecific, CEA TCB, RG-7802, RO-6958688
靶点;物种：Human CD66e/CEA/CEACAM5 & CD3E
种类：Humanized
受体鉴定：IgG1-kappa/lambdawithdomaincrossover
CAS: 2101242-53-7
存储条件：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.等相关疾病研究。
参考文献：
Three-dimensional colon cancer organoids model the response to CEA-CD3 T-cell engagers. PMID: 35154495
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. PMID: 30982469
Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid. PMID: 34959386
Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling. PMID: 33298591
Multi-Parameter Quantitative Imaging of Tumor Microenvironments Reveals Perivascular Immune Niches Associated With Anti-Tumor Immunity. PMID: 34421928
