标题：伊妥木单抗，Iratumumab，CAS: 640735-09-7，AntibodySystem Laboratories
货号：DHD80902
产品链接：http://www.atagenix.com/product_detail-75445.html
别名：MDX-060, CAS: 640735-09-7
简介：
Iratumumab (MDX-060) 是一种人抗 CD30 的 IgG1κ 单克隆抗体。Iratumumab 抑制表达 CD30 的肿瘤细胞的生长。 Iratumumab 可用于霍奇金淋巴瘤 (HL) 和间变性大细胞淋巴瘤 (ALCL) 的研究。
货号：DHD80902
产品品牌：Antibodysystem
通用名：Iratumumab
纯度：>95% by SDS-PAGE.
浓度：1mg/ml
Formulationicon：0.01M PBS, pH 7.4.
内毒素：Please contact with the lab for this information.
别名：MDX-060
靶点;物种：Human CD30/TNFRSF8
种类：Homo sapiens
受体鉴定：IgG1-kappa
CAS: 640735-09-7
存储条件：
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
参考文献：
Immunotherapy in indolent Non-Hodgkin's Lymphoma. PMID: 35663281
Gateways to clinical trials. PMID: 19088949
Invasive Fungal Diseases in Children with Hematological Malignancies Treated with Therapies That Target Cell Surface Antigens: Monoclonal Antibodies, Immune Checkpoint Inhibitors and CAR T-Cell Therapies. PMID: 33807678
Monoclonal antibodies in the treatment of non-Hodgkin's lymphoma. PMID: 17335294
Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells. PMID: 29721369
MDX-060. Medarex. PMID: 16370393
Current treatment and immunotherapy of Hodgkin's lymphoma. PMID: 16330443
TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species. PMID: 19890373
Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma. PMID: 17515574
