标题：恩弗利单抗，Envafolimab，CAS: 2102192-68-5，AntibodySystem Laboratories
货号：DHJ70104
产品链接：http://www.atagenix.com/product_detail-75183.html
别名：KN-035, CAS: 2102192-68-5
简介：
恩弗利单抗 Envafolimab (ASC 22; KN 035) 是人源化的单域抗 PD-L1 抗体的重组蛋白。Envafolimab 是由抗 PD-L1 结构域与人 IgG1 抗体的 Fc 片段融合而成。Envafolimab 阻断 PD-L1 和 PD-1 之间的相互作用，IC50 值为 5.25?nM。Envafolimab 具有研究实体瘤的潜力。
货号：DHJ70104
产品品牌：Antibodysystem
通用名；Envafolimab
纯度：>95% by SDS-PAGE.
浓度：1mg/ml
Formulationicon：0.01M PBS, pH 7.4.
内毒素：Please contact with the lab for this information.
别名：KN-035
靶点；物种：Human CD274/PD-L1/B7-H1
种类：Chimeric
受体鉴定：(VH-CH2-CH3)2
CAS：2102192-68-5
存储条件：
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
参考文献：
Envafolimab: First Approval. PMID: 35122636
Subcutaneous envafolimab monotherapy in patients with advanced defective mismatch repair/microsatellite instability high solid tumors. PMID: 34154614
First-in-Human Phase I Study of Envafolimab, a Novel Subcutaneous Single-Domain Anti-PD-L1 Antibody, in Patients with Advanced Solid Tumors. PMID: 33973293
Envafolimab - first PD-1/PD-L1 antibody to be administered by subcutaneous injection for microsatellite instability-high or deficient mismatch repair advanced solid tumors. PMID: 36124972
Phase I study of envafolimab (KN035), a novel subcutaneous single-domain anti-PD-L1 monoclonal antibody, in Japanese patients with advanced solid tumors. PMID: 35932387
Envafolimab combined with chemotherapy in the treatment of combined small cell lung cancer: A case report. PMID: 36874434
Case report: A case of complete clinical response in a patient experiencing high microsatellite instability unresectable colon cancer being treated with a PD-L1 inhibitor after interstitial pneumonia. PMID: 36998453
Design, synthesis, and preclinical evaluation of a novel bifunctional macrocyclic chelator for theranostics of cancers. PMID: 35347438
Residue-specific binding mechanisms of PD-L1 to its monoclonal antibodies by computational alanine scanning. PMID: 34259259
Noninvasive Imaging of Tumor PD-L1 Expression Using [99mTc]Tc-Labeled KN035 with SPECT/CT. PMID: 36541699
